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KMID : 0359819950240070794
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Journal of Korean Neurosurgical Society
1995 Volume.24 No. 7 p.794 ~ p.799
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Amyloid Deposits in Supratentorial Meningiomas
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이사우
손은익/송동식/임만빈/김인홍/박관규/서유헌
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Abstract
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Amyloidosis is the definition for a group of diseases that have, in common. the infiltration of one or more tissues by an abnormal protein material-the amyloid substance. which is detected histologically by their green polarization color after
Congo red
staining.
Despite increased interest on basic nature of amyloidosis by recent immunohistochemical of experimental study. the knowledge about the incidence and neurotoxic effect of cerebral amyloid or concomitant occurrence with brain tumor is still
inchoate.
We examined the incidence and clinico-pathologic characteristics of the patients with amyloid deposits in supratentorial meningiomas. particularly about their neurotoxic effect to adjacent brain is considered one of the possible cause of seizure
in
33
patients who underwent resection surgery for meningioma at the Keimyung University during the past three years.
The pathological review and subgrouping by histologci type were done in all 33 specimens with sufficient size of paraffin block. defined by their morphology and polarization color after Congo red staining for diagnosis of amyloid deposits
localized
in
the tumor. Immunohistochemical studies using monoclonal antibodies for amyloid-A protein (AA) and β-amyloid (Aβ) were evaluated to identify subtypes of amyloidosis.
The rate of incidence of amyloid deposit in meningioma was 21%, i. e. seven out of thirty three cases. All laboratory findings and clinical studies did not suggest a systemic form. Seizure occurrence was one out of seven cases (14%), which was of
no
statistical significance. Immunohistochemical study for AA subtype was all negative. but showed all positive for Aβ protein around the vessels. Recent reports has also demonstrated that Amyloid precusor protein (APP) and Aβ is related in
Alzheimer's
disease, hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA_D) and amyloid angiopathy.
Out research data indicates that the incidence of amyloid deposit is as high as 21% in supratentorial meningiomas. It seems that it is one of the possible cause of seizure. Nonsystemic microdeposits of amyloid and their subtype and it's
relationship to
neurotoxic effect in meningiomas remain to be confirmed by immunoelectron microscopic examination or immunohistochemical methods.
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KEYWORD
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